microscope platform (Mad City Labs)
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Mad City Labs
microscope platform
Microscope Platform, supplied by Mad City Labs, used in various techniques. Bioz Stars score: 94/100, based on 67 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rm21+platform/RM21+Microscope/pmc12996530-230-2-5
Average 94 stars, based on 67 article reviews
Microscope Platform, supplied by Mad City Labs, used in various techniques. Bioz Stars score: 94/100, based on 67 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rm21+platform/RM21+Microscope/pmc12996530-230-2-5
Average 94 stars, based on 67 article reviews
microscope platform - by Bioz Stars,
2026-09
94/100 stars
Images
1) Product Images from "Label-free mass and size characterization of few-kDa biomolecules by hierarchical vision transformer augmented nanofluidic scattering microscopy"
Article Title: Label-free mass and size characterization of few-kDa biomolecules by hierarchical vision transformer augmented nanofluidic scattering microscopy
Journal: Nature Communications
doi: 10.1038/s41467-026-70514-z
Figure Legend Snippet: A Schematic of the nanofluidic chip used. B Zoom-in on the nanofluidic part of the chip depicting the microfluidic inlet and outlet channels that connect to liquid reservoirs used to interface the chip holder and to a set of parallel nanofluidic channels used for NSM experiments. The length of the nanochannels is chosen such that they fit the field of view of the microscope at the desired magnification, and the cross-section of the nanochannels is tailored to the size of the molecule to be analyzed, as discussed in the main text. The two indicated channel dimensions correspond to the two nanochannel types used in the experiment depicted in ( D ). C The principle of differential imaging in NSM, in which we subtract the light scattered (yellow arrows indicate the scattered-light direction) by an empty nanochannel from the light scattered by the same channel with a molecule inside. A sequence of differential images of a nanochannel containing a diffusing single molecule obtained in this way is combined into a kymograph in ( D ), which then contains the full molecular trajectory. Here, this is exemplified for a Bovine Serum Albumin (BSA, MW = 66.8 kDa, R s = 3.5 nm) molecule differentially imaged in two nanochannels with different cross sections (defined by the widest and deepest points of the cross sections; see insets for cross-section scanning electron microscope images), i.e., and A I I I = 153nm × 32nm and A I V = 118nm × 30nm. While the trajectory of the BSA molecule is not resolved for the larger A I I I channel when only applying the standard data preprocessing steps outlined in the Methods section, it is clearly visible in the smaller channel A I V . This showcases the potential of lowering the LoD of NSM by reducing the nanochannel cross section area A , since A is inversely proportional to the LoD . For a more detailed statistical analysis of BSA and its dimeric oligomers, we refer to our seminal NSM work . Here, NSM denotes nanofluidic scattering microscopy, BSA bovine serum albumin, MW molecular weight, R s hydrodynamic radius, and LoD limit of detection.
Techniques Used: Microscopy, Imaging, Sequencing, Molecular Weight
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